3D reconstructed skin and epidermal models are a valuable tool in pharmaceutical and cosmetics testing, as well as for in vitro studies. 3D printing has shifted the paradigm in studies of experimental skin biology, as researchers moved from the 2D monocultures to growing skin within a 3D extracellular matrix. Companies like BASF Care Creations and Cell Therapy Research Institute CTIBiotech came together a few years ago to collaborate on new methods for bioprinting, working together to advance further in skincare applications. Now, they have announced the development of the first 3D bioprinted human reconstructed skin including immune macrophages. Macrophages are important cells of the immune system that are formed in response to an infection or accumulating damaged or dead cells. If these macrophages provide the first line of defense in protecting the host from infection, then researchers really needed to incorporate them in skin models.