Name: Dr. Mohammad Sadegh Azimi
Occupation: Research Associate, Vascular & Tissue Systems Engineering Lab
Institution: University of Virginia
What are you currently using CELLINK technology for?
We are currently using CELLINK supplies such as high-precision needles and syringes along with consumables. The image below depicts a three-layered jelly donut design structure with mesenchymal cells in red at the center and epithelial cells in green surrounding them. We use these constructs to study EMT in pancreatic cancers.
What sparked your interest to work with 3D Bioprinting?
Our current bio-printing effort is focused on understanding the Epithelial-to-Mesenchymal Transition (EMT) in pancreatic ductal adenocarcinoma (PDAC). We know that EMT contributes to the metastasis and chemoresistance in PDAC, and we are investigating the rules governing the process.
What future projects are you hoping to use CELLINK technology for?
We’re hoping to study the formation of functional blood vessel networks at the mid-level, arterioles and venules, in the near future. That requires careful considerations to find the best strategy for developing a multi-cell multi-system network.
What do you find to be most exciting about working with 3D Bioprinting?
3D bioprinting is a new multi-disciplinary field with a lot of potential applications, from tissue engineering to medical diagnostics. Therefore, it is required to have a multi-faceted outlook, and incorporate multiple areas of expertise within your team which is both challenging and exciting.