Name: Caitlyn Moore
Occupation: PhD Candidate
Institution: Rutgers New Jersey Medical School
What are you currently using CELLINK technology for?
I work in a Hematology/Oncology lab in which we primarily investigate bone metastatic breast cancer and cancer stem cells. A major point of focus for us is determining the mechanisms through which these cancer cells infiltrate the bone marrow and establish a dormant profile, making these cells chemoresistant. These dormant cells are the source of eventual cancer recurrence after remission. To address this huge clinical problem, we’re using the INKREDIBLE to create a 3D model of the perivascular niche of the bone marrow to study how the vascular microenvironment plays a role in initiating dormancy. We will then utilize this model to test different adjuvant therapies targeting these interactions, preventing dormancy and chemoresistance.
What sparked your interest to work with 3D Bioprinting?
The goal of my research is to improve patient outcomes. Entering a translational medicine-oriented lab as a biomedical engineer led me to look for ways to bridge the gap between the lab and the clinic. 3D bioprinting technology allows us to develop more physiologically relevant models to identify, validate, and screen therapies in the lab, subsequently boosting the efficiency of that therapy in pre-clinical and clinical arenas.
What future projects are you hoping to use CELLINK technology for?
I aim to work with CELLINK to build upon bone marrow model I am developing, introducing new cellular and molecular components to create an even more biomimetic model for us to study the bone marrow microenvironment in vitro. Also, I would like to dive deeper into the role of aging on the microenvironment and how this impacts dormancy. This is an important problem that needs to be addressed in order to better understand how bone marrow aging is tied to cancer recurrence.
What do you find to be most exciting about working with 3D Bioprinting
I love utilizing 3D bioprinting in my research, specifically its ability to shape-shift to the needs of your study, create realistic physiological models, and change the face research and healthcare. However, personally, the most exciting part about working with 3D bioprinting is the enthusiasm of the other people bioprinting all around the world. The energy that my colleagues bring to the biomedical field is equally intoxicating and inspiring. Trust me, you won’t find anyone more excited about their work than printing people!