Medical researchers have been able to create certain kinds of living cells with 3D printers for more than a decade. Now a few companies are getting closer to mass production of higher-order tissues (bone, cartilage, organs) and other individually tailored items, including implants. This kind of precision medicine, treating patients based on their genes, environment, and lifestyle, could herald the end of long organ donor lists and solve other problems, too.
Organovo Holdings Inc.
What Organovo has successfully transplanted human liver tissue into mice to cure chronic liver failure. Pending the success of human trials, possible applications include the $3 billion market for inherited conditions such as hemophilia.
Who Ten-year-old Organovo, co-founded by bioprinting pioneer Gabor Forgacs, a professor at the University of Missouri, has received more than $100 million in funding for its development of 3D-printed tissues. The company uses bioprinted tissue to test drug toxicity and effectiveness on behalf of Big Pharma companies including Bristol-Myers Squibb Co. and Merck & Co.
Next Steps The company says it plans to begin human clinical trials by 2020. It’s also developing printable bone tissue for skeletal disease research and co-developing 3D-printed skin with L’Oréal SA.
Aspect Biosystems Ltd.
What Aspect prints tissue cells to create structures that resemble parts of the human body, such as an airway or meniscus, to spur easier research on treatments for, say, asthma or muscle tears. By taking muscle cells from a lung, for example, the company built respiratory tissue that responded to common asthma inhalers as a person’s body should.
Who Engineering Ph.D. dropout Tamer Mohamed co-founded Aspect in 2013 with nanotechnology and biology experts. They’ve teamed with a Johnson & Johnson subsidiary to work on tissue development with their heavily customized printers.
Next Steps The focus of the J&J partnership is a prototype artificial meniscus that could be implanted without the need for more invasive and expensive knee surgeries. The companies haven’t set a timetable for human trials, though Mohamed says he’s hoping to get there in the next few years.