The new report of a chip from researchers in South Korea may represent the most advanced ex vivo model of a glioblastoma to date. The authors used bioprinting technology to put brain tumor cells from human patients on the chip alongside blood vessel.
The new model successfully mimicked the treatment responses seen in the patients from which the tumor samples were derived. Chip tumors from patients highly resistant to the standard glioblastoma treatment regimen—radiation combined with temozolomide—did not respond to therapy. Tumors printed from less resistant patients were, in turn, found to be more responsive to treatment.