3D Bioprinting Rebuilds the Human Heart

A new study describes a collagen scaffold tissue engineering technique that brings us one step closer to being able to three-dimensionally (3D) print a full-sized, adult human heart.

Developed by researchers at Carnegie Mellon University (CMU; Pittsburgh, PA, USA), the technique, called freeform reversible embedding of suspended hydrogels (FRESH), allows collagen to be deposited layer-by-layer within a the hydrogel support bath, giving it a chance to solidify in place before it is removed. Controlling the pH-driven gelation provides a 20-micrometer filament resolution porous microstructure that enables rapid cellular infiltration and micro-vascularization, allowing the fabrication and perfusion of multiscale vasculature and tri-leaflet valves.

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