Laminins are proteins composed of three subunits referred to as a α-chain, β-chain and γ-chain. They are a major component of the basal lamina that lines the external surface of cell membranes. This protein is characterized by its cross-like structure that serves as a structural foundation for many tissues. Laminins play an important role in cell differentiation, migration, adhesion and also involved in supporting healthy tissue. Several laminins have been identified, which all have been related to different tissues and organs in the human body.
Our CELLINK® LAMININ SERIES consists of five tissue-specific bioinks, LAMININK 111, LAMININK 121, LAMININK 411, LAMININK 521 and LAMININK+, that have been developed for improving maintenance and survival of tissue. The bioinks contain laminins to mimic the basal lamina and the natural tissue environment. These bioinks retain the excellent printability and ease of cross-linking found with the universal CELLINK® bioink.
CELLINK® LAMININK 121 can be utilized with several cell types and this bioink can be utilized as a great starting point for the culture of many cell types. Laminin 121 is widely expressed during embryonic and early development of the lining of tissues and organs. This laminin variation is also found predominantly in the placenta, skeletal muscle, and kidney tissue. CELLINK® LAMININK 121 is particularly suitable as a base material for the culture of several cell types, including skeletal muscle, brain, kidney and liver cells.