Laminins are proteins composed of three subunits referred to as a α-chain, β-chain and γ-chain. They are a major component of the basal lamina that lines the external surface of cell membranes. This protein is characterized by its cross-like structure that serves as a structural foundation for many tissues. Laminins play an important role in cell differentiation, migration, adhesion and also involved in supporting healthy tissue. Several laminins have been identified, which all have been related to different tissues and organs in the human body.
Our CELLINK® LAMININ SERIES consists of five tissue-specific bioinks, LAMININK 111, LAMININK 121, LAMININK 411, LAMININK 521 and LAMININK+, that have been developed for improving maintenance and survival of tissue. The bioinks contain laminins to mimic the basal lamina and the natural tissue environment. These bioinks retain the excellent printability and ease of cross-linking found with the universal CELLINK® bioink.
CELLINK® LAMININK 521 can be used as a great starting point for the culture of many cell types. Laminin 521 is the natural laminin for pluripotent and embryonic stem cells and therefore CELLINK® LAMININK 521 induces self-renewal of these cells. In addition, CELLINK® LAMININK 521 supports many diverse tissue cell types, such as cells from pancreas, vascular, nervous and muscular systems. Furthermore, the bioink can be used as a base for many specialized cells including hepatocytes, cardiomyocytes, and neurons.