This is a h1

bold

This is a h2

This is a h3

this is a h5

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

This is a button This is a button This is a button
This is a inline form field

Submit
Small button

Wide button 100%

This is a h1

bold

This is a h2

This is a h3

this is a h5

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

Mobile image fallback

3D Bioprinting

Together we create the future of medicine

By using bioink in combination with a bioprinter, researchers around the world are able to take the next step in regenerative medicine. With our bioinks and bioprinters, we can take Your research to the next level.

Cellink frontpage background

Bioprinting
technology

Bioprinting utilizes 3D-printing technology combined with bioink to create complex 3-dimensional structures. By using bioink the structures can be built with living cells to create real, living tissue. The additive technique ensures precision and flexibility when it comes to the placement of cells and different cell types. The bioprinting technology opens up for a wide range of different applications. For example, bioprinting in bone cells, skin cells or tissues for internal organs. These tissues can then be used for oncology research, drug testing, high-through-put drug screening or testing of cosmetic compounds

Bioinks creating new opportunities

CELLINK is the first bioink company in the world and is also the creator of the world’s first universal bioink. This opens up the opportunity for scientists to bioprint using any type of cells. CELLINK also provides a wide range of bioinks for different applications. A bioink is a hydrogel biomaterial that is suitable for bioprinting and it provides a temporary support to the cells while they produce their own extracellular matrix.

Featured in:

"As a customer that ordered the Dual-head INKREDIBLE Bioprinter, I would like to sincerely thank the staff for making the purchase easy and to the point. CELLINK was incredibly receptive and supportive throughout the process. I would highly recommend CELLINK as the first stop for anyone interested in entering the field of bio-printing at minimal cost."

Konkuk University, Department of Biomedical Science

INCREDIBLE
+ 360° view

Bioprint right on the lab-bench with our patented Clean Chamber Technology. With a HEPA filtered positive air pressure inside the printing chamber you can be sure that your bioprinting is sterile. We take your research seriously, just like we know you do.

Bioprinting
technology

Let's work together!

Be part of the movement. We provide experts and educators all over the world with the most cost-effective yet highly reliable 3D Bioprinting system.

Bioink

3D Bioprinting of human tissues and organs is revolutionizing the field of tissue engineering and thus, the future of medicine. We believe we can create this future through a collaborative spirit with scientist all over the world and by putting our combined expertise to the service of humanity.

What is a bioink?

A bioink is a hydrogel biomaterial that is suitable for bioprinting with mammalian cells and it provides a temporary support to the cells while they produce their own extracellular matrix. Significant advances in 3D bioprinting technology as well as development of new bioinks have made it possible to bioprint complex 3D tissue structures [1]. Bioinks based on biopolymers (e.g. collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose) are known for their favorable biocompatible properties and are attractive biomaterials for cell encapsulation and 3D bioprinting. These bioinks provide an aqueous 3D environment with biologically relevant chemical and physical signals, mimicking the natural extracellular matrix environment.

However, the application of some bioinks for 3D bioprinting of organs with clinically relevant dimensions can be challenging due to their sub-optimal printability [2]. For example, a common challenge when 3D bioprinting alginates is the poor shaped

Bioinks

Even minor deformities, whether is an actual or perceived defect, bring psychological distress upon the affected individuals, especially children. An outer appearance with life-like limbs and tissues is important for their psychological and emotional well-being. For these reasons, tissue engineers, biologists, material scientists, and clinicians have an invested interest and passion to develop a successful clinical therapy for reconstruction through a tissue engineering approach using the patient’s own cells. The innovative methods for engineering human tissues and organs can have a profound effect on the future of medicine. 3D Bioprinting is considered a revolutionizing technology for advancing and accelerating progress in the field of tissue engineering and regenerative medicine. and thus, the future of medicine. We believe we can create this future through a collaborative spirit and by putting our combined expertise to the service of humanity.

The future is created in the present and it belongs to the doers, those that continue moving forward in order to see their vision come to realization. It’s not that we see the future and then move towards it. We move in order to see it.

[1] Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR. Organ printing: computer-aided jet-based 3D tissue engineering. Trends in Biotechnology. 2003;21:157-61.

[2] Malda J, Visser J, Melchels FP, Jungst T, Hennink WE, Dhert WJ, et al. 25th anniversary article: Engineering hydrogels for biofabrication. Advanced Materials. 2013;25:5011-28.

[3] Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32:773-85.

[4] Giannitelli SM, Accoto D, Trombetta M, Rainer A. Current trends in the design of scaffolds for computer-aided tissue engineering. Acta Biomaterialia. 2014;10:580-94.

MORE PUBLICATIONS:
[Langer, R. & Vacanti, J. P. Tissue engineering. Science 260, 920-926 (1993). Griffith, L. G. & Naughton, G. Tissue engineering--current challenges and expanding opportunities. Science 295, 1009-1014, doi:10.1126/science.1069210 (2002). Murphy, S. V. & Atala, A. 3D bioprinting of tissues and organs. Nat Biotechnol 32, 773-785, doi:10.1038/nbt.2958 (2014).

Bioprinting of human tissues and organs

3D Bioprinting of human tissues and organs is revolutionizing the field of tissue engineering and thus, the future of medicine. We believe we can create this future through a collaborative spirit with scientist all over the world and by putting our combined expertise to the service of humanity

3D Bioprinting

A major challenge in tissue engineering and stem cell research has been to mimic the micro and macro environment of human tissues. A satisfying functional outcome is highly dependent on the level to which tissue scientist and engineers can control the inner micro- and macro-scale features of the engineered-tissue. In response to this need, advances in additive manufacturing inspired scientists to develop and adapt this technology for bioprinting of human tissues and organs [1].

Why Bioprinting?

As Stuart K. Williams, Ph.D, from the university of Louisville says "It's just a pump with tubes you need to connect" but we are not there yet, it's all about the " strategic placement of the valves and big vessels", this would be achievable within a decade he asserts. However, what can be done today is the bioprinting of tissue like cartilage, skin, or liver. Such tissue can be used in drug discovery where researchers can test new potential treatments and evaluate efficacy in very early stages. This process allows us to produce more realistic and functional models of what is truly happening at the cellular level as opposed to 2D cell culturing, where cells are not expanding in a proper 3D environment. As a result, new drugs and treatments will reach clinical trials faster with a decreased number of failures and reduced need of animal testing. In cosmetology, for instance, the goal everybody is striving for is to completely eradicate the need of animal trials, which companies such as Organovo, L'Oreal, BASF, Poietis are currently working on by developing skin tissue models.

One has to remember, the process of printing the actual tissue structure is a critical step, but the most essential one is the culturing of the bioprinted constructs in order to have the cells grow and proliferate. Therefore, the focus must be on the cell friendly and supporting material. Much like the typical paper printer, the magic is in the ink.

Bioinks

Even minor deformities, whether is an actual or perceived defect, bring psychological distress upon the affected individuals, especially children. An outer appearance with life-like limbs and tissues is important for their psychological and emotional well-being. For these reasons, tissue engineers, biologists, material scientists, and clinicians have an invested interest and passion to develop a successful clinical therapy for reconstruction through a tissue engineering approach using the patient’s own cells. The innovative methods for engineering human tissues and organs can have a profound effect on the future of medicine. 3D Bioprinting is considered a revolutionizing technology for advancing and accelerating progress in the field of tissue engineering and regenerative medicine. and thus, the future of medicine. We believe we can create this future through a collaborative spirit and by putting our combined expertise to the service of humanity.

The future is created in the present and it belongs to the doers, those that continue moving forward in order to see their vision come to realization. It’s not that we see the future and then move towards it. We move in order to see it.

[1] Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR. Organ printing: computer-aided jet-based 3D tissue engineering. Trends in Biotechnology. 2003;21:157-61.

[2] Malda J, Visser J, Melchels FP, Jungst T, Hennink WE, Dhert WJ, et al. 25th anniversary article: Engineering hydrogels for biofabrication. Advanced Materials. 2013;25:5011-28.

[3] Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32:773-85.

[4] Giannitelli SM, Accoto D, Trombetta M, Rainer A. Current trends in the design of scaffolds for computer-aided tissue engineering. Acta Biomaterialia. 2014;10:580-94.

MORE PUBLICATIONS: [Langer, R. & Vacanti, J. P. Tissue engineering. Science 260, 920-926 (1993). Griffith, L. G. & Naughton, G. Tissue engineering--current challenges and expanding opportunities. Science 295, 1009-1014, doi:10.1126/science.1069210 (2002). Murphy, S. V. & Atala, A. 3D bioprinting of tissues and organs. Nat Biotechnol 32, 773-785, doi:10.1038/nbt.2958 (2014).

Bioink and it’s properties

Ideally, the bioink should exhibit a high zero-shear viscosity, shear-thinning behavior and rapid gelation in order to maintain a high shape fidelity during the bioprinting process. In addition to having good printability, the bioink should also provide a biologically relevant 3D environment that supports cell fate processes, such as cell attachment, proliferation and differentiation.


Our bioinks provide mammalian cells with a milieu that resembles their natural matrix while their printability makes it possible to bioprint complex, cell-laden constructs. When you are looking for an ideal solution to all your 3D Bioprinting and 3D cell culturing needs you can count on CELLINK to deliver the results you are looking for. CELLINK provides sterile and ready-to-use bioinks in 3mL and 10mL cartridges, adapting to your bioprinting needs and size of your desired bioprinted structure.

Request a demo

Support

CELLINK is Your partner in 3D bioprinting. Our team consists of experts from different areas, from biotechnology to computer science, all in pursuit of the best 3D bioprinting process and experience. If you run into difficulties or want to develop your 3D bioprinting process, do not hesitate to contact us!

CELLINK Pluronic® F-127

CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment.

GelMA is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959 or lithium acylphosphinate salt, LAP) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process.

CELLINK Pluronic® F-127

CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment.

GelMA is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959 or lithium acylphosphinate salt, LAP) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process.

CELLINK Pluronic® F-127

CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment.

GelMA is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959 or lithium acylphosphinate salt, LAP) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process.

CELLINK Pluronic® F-127

CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment.

GelMA is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959 or lithium acylphosphinate salt, LAP) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process.

CELLINK Pluronic® F-127

CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment.

GelMA is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959 or lithium acylphosphinate salt, LAP) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process.

CELLINK Pluronic® F-127

CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment.

GelMA is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959 or lithium acylphosphinate salt, LAP) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process.

Pluronic® F-127

Feature

Bioprinter features 1 Bioprinter features 2
Incredible + Incredible
Printing technology Pneumatic extrusion Pneumatic extrusion
Dual print heads Incredible Dual print heads Dual print heads 1
Heated cartridges Incredible Heated cartridges Heated cartridges 2
Clean Chamber Technology Incredible Clean Chamber Technology 1 Clean Chamber Technology 2
Build Volume 130 x 80 x 100 130 x 80 x 50
Outer dimensions 300 x 320 x 430 300 x 320 x 380
Connectivity SD-card, USB SD-card, USB
UV crosslinking system 365nm standard, 405 nm option 365 nm UV-LED
Printing resolution 10 microns 10 microns
Printhead actuation Prenumatic high precision Mechanical

Feature

Printer 2 fetaures
Incredible
Printing technology Pneumatic extrusion
Dual print heads Dual print heads
Heated cartridges Printing technology Heated cartridges
Clean Chamber Technology Printing technology Clean Chamber Technology
Build Volume 130 x 80 x 50
Outer dimensions 300 x 320 x 380
Connectivity SD-card, USB
UV crosslinking system 365 nm UV-LED
Printing resolution 10 microns
Printhead actuation Mechanical

Feature

Incredible features
Incredible +
Printing technology Pneumatic extrusion
Dual print heads Incredible + Dual print heads
Heated cartridges Incredible + Heated cartridges
Clean Chamber Technology Incredible + Clean Chamber Technology
Build Volume 130 x 80 x 100
Outer dimensions 300 x 320 x 430
Connectivity SD-card, USB
UV crosslinking system 365nm standard, 405 nm option
Printing resolution 10 microns
Printhead actuation Prenumatic high precision

Application

Cartilage Skin Bone Muscle MSCs Sacrificial material
Cellink Bioink applications Cartilage Bioink applications Skin Bioink applications Bone
Cellink RGD Bioink applications Muscle Bioink applications MSCs Bioink applications Sacrificial material Bioink applications Sacrificial material 2
Cellink bone Cellink Bone
Cellink A Cellink A Cellink A 2
Cellink A-RGD Cellink A-RGD Cellink A-RGD 2 Cellink A-RGD 3
Cellink GelMa Cellink GelMa 1 Cellink GelMa 2 Cellink GelMa 3 Cellink GelMa 3
Cellink PCL Cellink PCL 1 Cellink PCL 2 Cellink PCL 3
Cellink: Pluronics Cellink: Pluronics
Cellink Start Cellink Start

FAQ

Video

Contact

Table

Category Version File
Manual INKREDIBLE Bioprinter N/A Download
Manual INKREDIBLE+ Bioprinter N/A Download
CELLINK MSDS Bioink N/A Download
CELLINK A MSDS Bioink N/A Download
CELLINK MSDS Bioink N/A Download
CELLINK Support MSDS Bioink N/A Download
CELLINK Start MSDS Bioink N/A Download
Application note Bioink N/A Download